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Thus, CHAC1 exacerbates arsenite cytotoxicity by degrading GSH and promoting apoptosis in response to arsenic exposure (Sumi et al., 2023)

Hepatocyte growth factor inhibits CNS autoimmunity by inducing tolerogenic dendritic cells and CD25+ Foxp3+ regulatory T cells

Age-related mitochondrial dysfunction and metabolic disorders

Numerous studies have shown that the apoptotic pathway is involved in the pathogenesis of these diseases, and it is activated only as a last resort when there is no possibility of neurons recovery ( Neurodegenerative diseases are characterized by the slow, progressive loss of neuronal cells in the central nervous system (CNS) and the aggregation of misfolded proteins (Singh et al., 2019)