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His physique was thin and soft, due to his extremely high metabolism
doi:10.1007/s00296-014-3047-6

This is a comprehensive review focusing on the anti-inflammatory and neuroprotective role of melanocortins in the CNS

In line with our findings, other publications have reported that UCP1 and PGC1 expression is increased in the BAT of ATF4-whole body knockout mice, suggesting that ATF4 can act as a negative regulator of uncoupled respiration (Wang et al, 2010)