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However, there is no consensus on the mechanism by which risdiplam promotes SMN2 exon 7 inclusion with high specificity [147]

Higher Doses: Doses up to 4000 mg/day were studied but did not consistently show additional benefits over 2000 mg/day

doi:10.1111/jsr.12956 Liu HM, Chiang IJ, Kuo KN, Liou CM, Chen C
