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The current research is compelling, but more research is needed
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While several subtype-specific therapeutic approaches have been identified for SCLC 36,37,38,39,40,41 , recent evidence suggests that SCLC subtype intratumoral heterogeneity may evolve as a consequence of subtype plasticity 5 highlighting the need to devise therapies targeting SCLC plasticity rather than isolated molecular subtypes
A Pew Research Center survey from February 2026 found that 49% of U.S
