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Interestingly, a recent study expressing human KCNQ2/3 on Xenopus laevis oocytes showed that BHB can effectively activate the KCNQ2/3 heterotetrameric channel at physiologically relevant concentrations (~0.1 mM) by directly interacting with a tryptophan residue located on a transmembrane segment of the KCNQ3 subunit, thus eliciting neuronal hyperpolarization (Manville et al., 2020)

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