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OARSI-FDA initiative: defining the disease state of osteoarthritis
doi: 10.1002/14651858.CD010223.pub2 65 WichmanJWintherKHBonnemaSJHegedsL
The Glutathione Peroxidases
It is important to note that, at the time points when we observed GPX4 level reduction under cystine starvation, there was no obvious ferroptosis induction (or any cell death) in these cell lines (most of which, such as UMRC6 and NCI-H226 cells 24 , exhibit high SLC7A11 expression and are ferroptosis resistant)
