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A common taper protocol is to reduce the dose by 25% each week (e.g., 1mg to 0.75mg to 0.5mg to 0.25mg, then stop) or extend the interval between injections (nightly to every other night to every third night)

Fortunately, Vitamin B-12 is a water soluble vitamin that will be naturally eliminated by the body when the amount needed is exceeded

therefore, avoidance or care should be taken with co-administration of cetirizine with p-glycoprotein substrate drugs