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For most nano-phytomedicines, an optimal hydrodynamic diameter of 50150 nm balances circulation time, endothelial uptake, and diffusion within the brain parenchyma, which is why SLNs, NLCs, PLGA NPs, and liposomes designed for CNS targeting typically fall within this range (118)

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AOD-9604 is not a drug, supplement, or food product, and is not for human consumption, veterinary use, or medical applications

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