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Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial
Notable elevations of ALT or AST (approximately three or more times the upper limit of normal) have been reported in approximately 1% of patients in clinical trials with NSAIDs
Another trigger for the induction of the MPTP in the context of APAP-induced liver injury is lysosomal iron, whose translocation to the mitochondria has been shown to occur in mouse hepatocytes treated with APAP, where it then induced opening of the MPTP75
