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In a meta-analysis, combining five RCTs (including three smaller ones from Iran, Ireland, and China), vitamin D intervention was associated with a moderate reduction in ASD severity (pooled SMD for symptom scales = 0.49, 95% CI: 0.85 to 0.13, p = 0.008) [85]

WADA Prohibition The World Anti-Doping Agency explicitly prohibits AOD-9604 for competitive athletes: Listed under Section S0 (Non-Approved Substances) and S2.2.3 (Growth Hormone Fragments) Prohibited at all times (both in-competition and out-of-competition) No Therapeutic Use Exemptions (TUEs) available Detection methods developed and implemented in anti-doping laboratories worldwide WADAs 2013 statement clarified that AOD-9604 is a substance still under pre-clinical and clinical development and has not been approved for therapeutic use by any government health authority in the world. Research Classification: AOD-9604 is available only for laboratory research use