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A potential use of vidarabine: Alleviation of functional constipation through modulation of the adenosine A2A receptor-MLC signaling pathway and the gut microbiota
Studies utilizing metformin reported lower levels of TNF-, S6K, IL-1, and mTOR in the PFC [74, 75]

Another important signalling molecule related to SIRT1 is the AMP-activated protein kinase (AMPK), which acts as an initial sensor to increase the level of NAD + [346]
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