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The meta-analysis of these trials included thousands of patients

Dose Rate: Dairy and beef cattle: Suggested supplementation program: Bulls: 3 months before joining and at joining Beef cows: 4 weeks before mating and 4 weeks before calving Dairy cows: 4 weeks before calving, 4 weeks before mating or insemination and 4 weeks before drying off Calves: At marking and weaning Heifers: Every 3 months and 4 weeks before mating Additional: Every 2 months in wet conditions Critical Comments: Following withdrawal of the first dose, the unused product should be discarded after 9 months

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doi: 10.3389/fonc.2023.1155254