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Description
AKT also phosphorylates the pro-apoptotic and anti-proliferative transcription factor FOXO1, which leads to its exclusion from the nucleus and cytosolic degradation, thereby connecting tumor cell metabolism with cell cycle progression and survival
Interestingly, the ability of surviving persisters to grow during treatment is also affected by FAO and ROS, as cycling persisters have higher FAO scores while controlling ROS levels more efficiently than the more abundant non-cycling persisters 38
doi: 10.1042/BJ20101784
doi: 10.1042/cs0960549
