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maximum plasma concentrations are reported 3060 min after oral intake, and it has an estimated half-life between 28 and 40 min in both humans and mice [46,47,48]
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Mechanistically, NNMT depletion reduced the consumption of methyl donors, increasing protein phosphatase2A (PP2A) methylation
doi: 10.1016/S0002-9610(02)00823-1
