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Targeting IGF-1R in cancer The vast expression of IGF-1R in neoplastic cells and tissues combined with its crucial roles in cancer cell growth is making this tyrosine receptor an attractive target to combat malignant diseases

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Sixteen prospective studies of patients (total sample size of 1677 subjects) randomized to NAC administered either orally or intravenously versus a control group (842 assigned to high-dose NAC, 835 to the control arm) were included in this meta-analysis