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Beyond the observed increase in female lifespan, we show that pharmacologic blockade of IGF-1R signaling preserves, to various degrees, many aspects of healthspan, including neuromuscular function and endurance, and attenuates the age-related increase in diastolic dysfunction, systemic inflammation, and neoplasias in females

[(Pre-Coupling Solution x D) - (Post-Coupling Solution x D)] x 100/(Pre-Coupling Solution x D) where D = dilution factor

Third, select node-specific therapy tailored to that map (e.g., NOX isoform modulation, RET tempering and mitochondrial quality control, UPR^ER tuning, iron/ferroptosis control, NOS re-coupling, RSS support) and co-prescribe lifestyle measures (structured exercise, nutrition, sleep/circadian alignment and exposure control) that reset redox tone without erasing adaptive cues (Meng et al