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This damage reduces their effective function and can trigger apoptosis or macroautophagic mitochondrial recycling (also known as mitophagy)

Because GSH status is dynamic, the outcome measures were extended beyond GSH status alone to include 8-OHdG and F2-isoprostanes (F2-isoP), in case a change in oxidation status was exemplified by evidence of reduced oxidation products rather than a change in GSH or GSH:GSSG ratio (i.e., improvement in tissue-level oxidative stress not represented by RBC indices)

Ethical debates often center on treatment risks, side effects, safety, and societal impact (138)

Megaintestine in claudin-15deficient mice