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To avoid and manage these problems, one approach is Robert and Szabos concept of cytoprotection, which holds innate cell (epithelial (Robert) [41,42,43] endothelial (Szabo) [43,44,45,46,47]) integrity and protection/maintenance/reestablishment in the stomach to be translated to other organ therapy (cytoprotection organoprotection) [48,49] via the cytoprotection agents effect

PLoS ONE 7 , e42341 (2012)

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On the contrary, the metal(II)-bis-glutathionato conjugates retains the structural motifs for recognition by the glutathione disulfide binding site of the enzyme but are able to kinetically exchange the metal with other thiolates, through the mechanism reported in Section 2