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AOD-9604 Research Applications & Key Findings Metabolic and Obesity Research Weight Loss and Fat Reduction Studies Initial clinical trials in obese adults showed promising results, though later studies revealed limitations

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2017 NNMT knockdown in adipocytes was associated with improved markers of insulin sensitivity and glucose uptake in preclinical in vitro models, linking NNMT to metabolic homeostasis

Because the peptide works specifically through beta-3 adrenergic receptors in adipose tissue and does not affect growth hormone receptors, IGF-1, or glucose metabolism, it does not create the compounding effects or interaction concerns associated with growth hormone therapy