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For the identification of druggable targets, we considered three classes of enzymes: tier-1 targets, tier-2 targets, and other enzymes. Tier-1 targets correspond to enzymes whose knockout impedes viral replication while having a minimal impact on the simulated cellular viability

In WT mice, although cagrilintide treatment led to significant weight loss, the changes in body composition compared to vehicle-treated mice did not reach statistical significance, with fat mass decreasing by 7% ( P = 0.2) and lean mass increasing by 5% ( P = 0.14

References Su, Z., Yang, Z., Xu, Y., Chen, Y

1 H NMR spectroscopy analysis showed a large shift of two protons, H1 and H2 in Cys solution containing Hg (Supplementary Figure 2)