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These neuroprotective effects were due to the upregulation of NAD+-dependent Sirtuin 3 (SIRT3) and its downstream substrates, superoxide dismutase 2 (SOD2) and forkhead box O3A (FOXO3A) in the penumbra area (43)
Liver Int 42(9):19992014 Li R, Wu H, Xu Y, Xu X, Xu Y, Huang H,

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aureus and other species secrete virulence factors that directly disable immune cells