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The characteristics of CAR-T cell exhaustion include reduced cytokine production, decreased proliferative capacity, and sustained high expression of inhibitory receptors such as PD-1, LAG-3, TIM-3, or CLTA-4 (144)

Yet as far as understanding emotional odours is concerned, we are now reaching a point where uncertainty over mechanism may constrain further progress

Glossary Apoptosis A caspase-dependent programmed cell death pathway controlled by the BCL-2 protein family and mitochondrial factors that maintains tissue homeostasis and eliminates damaged or unwanted cells in a controlled manner by orchestrating distinct cellular changes, including chromatin condensation, DNA fragmentation and membrane blebbing