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2001 in Endocrinology showed reduced body weight gain with 14-day AOD-9604 in obese (ob/ob) mice and identified the beta-3 adrenergic receptor dependency

The preclinical data creates false confidence that may not translate to humans

More specifically, the superior mesenteric vein, inferior and superior anterior pancreaticoduodenal, pyloric vein, and portal vein in the superior mesenteric vein-portal vein shunt reestablish the interrupted superior mesenteric and portal vein pathway (the occluded end of the superior mesenteric vein) (Knezevic et al., 2021b)

Those with known peptide allergies or certain severe autoimmune conditions could be at elevated risk