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Overall, microbially produced metabolites act as potent CNS regulators, either by modulating the vagus signaling and systemic immunity or by directly crossing the BBB ( 3.7.4 Radiation-induced injuries and microbial mediation Radiation-induced injuries initiate local and systemic responses, which are closely related to the gut microbiome's integrity

ROS production and associated inflammation are closely related to aging and numerous chronic diseases as diabetes, cardiovascular atherosclerosis-related diseases (144, 145) and respiratory diseases, known risk factors for developing severe illness and death in patients with SARS-CoV-2 and COVID-19 disease

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