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Eur Heart J (2018) 39(1):609

Specifically, TET1 deficiency has been linked to increased tumor cell invasion and enhanced xenograft tumor growth in breast and prostate cancer models, highlighting its potential as a therapeutic target (Cheng et al

Study designs should also incorporate prospective biospecimen collection to map changes in myeloid composition, dendritic-cell maturation and vascular cues under NGF/TrkA or BDNF/TrkB blockade, and explore dendritic cellbased vaccines that leverage Trk expression on antigen-presenting cells as complementary immunotherapy strategies