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366,367 In earlier clinical studies, the suitability of the population for intensified treatment remains unclear, with inconsistent intensity and duration of CDK4/6 inhibitors and inadequate management of their toxic side effects

Importantly, recent preclinical studies demonstrate that, like rimonabant, neutral antagonists of CB1 reduce self-administration of 9 -THC and nicotine, and can also prevent cue-induced reinstatement of 9 -THC, nicotine, and cocaine seeking (Gueye et al., 2016

The anti-inflammatory effect of AGK2 is manifested in reducing the expressions of IL-6, TNF-, and IL-1 in renal tissue induced by CLP, thereby alleviating inflammatory response and elevating the survival rate of SAKI model mice (Yu et al., 2025)

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