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One well-known SNP (SNP A118G) causes the loss of an N-glycosylation site on the extracellular portion of the receptor, altering ligand-receptor binding1 and thereby diminishing the clinical response to opioids

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G protein-coupled receptor ghrelin growth hormone secretagogue receptor pharmacology receptor dimerization Significance Statement The growth hormone secretagogue receptor, a key component of the ghrelin system, is important in many processes, including feeding behavior, stress, and reward

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