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Mechanisms of carcinogenesis: focus on oxidative stress and electron transfer

A study in a rat uterine fibroid model demonstrated that reducing serum E 2 levels was accompanied by increased GSH content, thereby alleviating the extent of oxidative damage [68]

The hypothesis of the gain of function in GCase theorizes that the mutant form of protein is recognized as misfolded, thus placing stress on mechanisms of protein degradation and interfering with -synuclein breakdown and consequent endoplasmic reticulum stress, as observed in autophagy perturbations in cells derived from patients with GBA1 -associated PD (Fernandes et al., 2016)