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What they found: Preventive administration: 70 to 85 % reduction in ulcer area Therapeutic administration: 60 to 75 % reduction And now the most interesting part: 10 ng/kg worked just as well as 10 g/kg Why it matters: If the molecule worked in a stoichiometric way (= simply blocking something piece by piece), a higher dose would necessarily produce a larger effect

This property can be advantageous for applications requiring drug penetration into specific tissue compartments

Blinding to animal identity was not possible as investigators needed to evaluate the range of immunoreactivity across groups to determine intensity thresholds

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