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Description
Since the respiratory chain of mitochondria contains a large amount of molecular oxygen it is predisposed to radical generation

J.McIntyreT
Proc Natl Acad Sci USA 1985

Consistent with this model, NRF2 activation promotes transcription of genes involved in redox homeostasis and glutathione biosynthesis, including Gclc and Gclm (41, 63)
