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The functional interactome of GSTP: A regulatory biomolecular network at the interface with the Nrf2 adaption response to oxidative stress

Tight junction proteins are closely regulated, which is imperative for the maintenance of normal barrier integrity

When PLOOH is not rapidly neutralized as an PLOH by glutathione peroxidase 4 (GPX4) in time, PLOOH further reacts with ferrous ions, and the resulting lipid radicals, such as alkoxyl phospholipid radicals (PLO) and PLOO, react with PUFA-PLs ( 2 produced by the mitochondrial tricarboxylic acid (TCA) cycle and the reduction of nitrogen oxides by NADPH produce H 2 O 2 catalyzed by superoxide dismutase (SOD) and participate in the Fenton reaction of iron ( Figure 1A )

GHK-Cu, the Glow blend, and Glutathione compared by mechanism