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Inflammation also shifts tryptophan metabolism away from serotonin to neurotoxic kynurenine pathway metabolites, like quinolinic acid, and disturbs neurotransmission and thus plays a role in depressive symptoms (Liang et al., 2024)

Insulin-like growth factor (IGF-1) is another mediator potentially involved in IPF development

Chen T, Wu DI, Chen H, Yan W, Yang D, Chen G, et al

Mousset A, Lecorgne E, Bourget I, Lopez P, Jenovai K, Cherfils-Vicini J, et al
