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The transcriptional upregulation of Ppara and Ppargc1a observed here reflects glucagon-driven mitochondrial activation [49], while the downregulation of lipogenic genes ( Fasn , Scd2 ) may stem from GIP receptor activation in adipocytes, redirecting nutrient flux away from storage
Pharmacol Rev 63(1):134
Induction of mGlu2 receptors is mediated by acetylation mechanisms that involve transcription factors of the nuclear factor (NF)-B family
