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The main drivers are pigmentation type and depth, your skin tone, the number of sessions needed, and whether prescription topicals, oral support, or IV therapy are included

doi: 10.1016/0014-2999(94)00727-o

Sulfonation reactions are catalyzed by sulfotransferases (SULT) and involve the transfer of a sulfonate group (-SO3) from a cofactor (PAPS - 3'-phosphoadenosine-5'-phosphosulfate) onto a nucleophilic xenobiotic

After the initiation of folic acid fortification, mean plasma folate concentrations increased from 4.6 to 10 ng/mL, homocysteine concentrations fell from 10.1 to 9.4 mol/L, and the prevalence of homocysteine levels above 13 mol/L dropped from about 19% to about 10%