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The molecular mechanisms driving these effects include inhibition of ATP-sensitive potassium channels in pancreatic beta-cells to stimulate insulin release, activation of the glucagon-like peptide-1 (GLP-1) receptor or inhibition of dipeptidyl peptidase-4 activity to enhance incretin signaling and lower circulating glucose levels, and activation of the peroxisome proliferator-activated receptor-gamma (PPAR) in adipocytes to improve insulin sensitivity in peripheral tissues (25)

Not too long after I turned 60 I noticed I was starting to feel weak and tired, had a hard time sleeping, had headaches all the time, low appetite (which is unusual for me as Ive always had a strong appetite), have heart palpitations, felt light-headed at times, and just seem to have lost my zest to go out and do things

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