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By the same token, glial involvement is not necessarily inflammatory but may also alter CNS function via non-inflammatory mechanisms, e.g., neurovascular coupling (NVC) and thus blood flow distribution, modulating synaptic functions and thus neuronal connectivity and signaling, or even, especially in the case of oligodendrocyte involvement, by altering myelination

Haake J, Steenpass L

Stringer RN, Weiss N (2023) Pathophysiology of ion channels in amyotrophic lateral sclerosis

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