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WHO has prepared a number of detailed and illustrated publications in recent years on the classification of renal disease (WHO 1982, l985, 1987, 1988)

Such damage disrupts the ability of neurons to transmit nerve impulses, resulting in a widespread of disease manifestation and numerous symptoms including physical, sensorial, cognitive, and sometimes psychiatric problems (Miller et al., 2005)

As aquaporin-4 is mainly localized in the astrocyte endfeet, these are the primarily affected cells in this disease

Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of Homer-related, synaptic proteins