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Additional intracellular stressors, such as phagosome acidification and nutrient deprivation, also contribute to tolerance 10

For instance, JAG2-overexpressing ovarian cancer cells can activate Notch receptors on MCs, leading to increased IL-6 secretion, which in turn promotes tumor cell survival and chemoresistance [79]

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To evaluate whether biguanide effects on ether lipid synthesis are induced through a direct effect on the worm or via alterations in bacterial-host dynamics, we leveraged a robust, established methodology to chemically kill and metabolically inactivate the C