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Impairment of the PINK1/Parkin pathway disrupts mitophagy, exacerbating mitochondrial dysfunction and mtROS burst

The World Mental Health (WMH) survey, using the WHO Composite International Diagnostic Interview (CIDI 3.0), identified BD as one of the most disabling psychiatric conditions, with affected individuals averaging 41.2 days of role impairment per year 36.5 of which were directly attributed to BD (Nierenberg et al., 2023)

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DHLA is also able to reduce ubiquinone (CoQ10) to ubiquinol, which is an important component of the mitochondrial electron transport chain (Bast and Haenen, 2004)