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Their availability and procurement methods are also distinct

Low Dose Naltrexone (LDN) works primarily by: Temporarily blocking opioid receptors , which paradoxically leads to an increase in the bodys production of endorphins (natural painkillers and immune modulators) Modulating the immune system , particularly by inhibiting the activity of microglia - inflammatory cells in the brain and spinal cord that are implicated in pain, fatigue, and cognitive dysfunction These mechanisms make LDN a compelling candidate for conditions that involve central sensitization , neuroinflammation , and immune dysregulation - all of which are increasingly recognized as core features of EDS, HSD, ME/CFS, and related disorders

The main clinical monitoring points are IGF-1 levels and fasting glucose, as GH can transiently affect insulin sensitivity

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