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127 A phase 2 study evaluating the co-administration of bremelanotide with tirzepatide for the treatment of obesity (Bmt-801)
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By targeting both glucagon-like peptide-1 and glucose-dependent insulinotropic peptide receptors, tirzepatide reduces hunger signals, slows gastric emptying, and improves insulin sensitivitymechanisms supported by Phase 3 SUMO clinical trials showing 22.5% weight reduction over 68 weeks
These mitochondrial alterations may help explain why neuropathy often persists well beyond the end of treatment
