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Description
This occurs through the downregulation of cyclin D1 and CDK4/6 and the upregulation of cell cycle inhibitors such as p21 and p27
In addition, THADA can cause apoptosis in cells by activating the death receptor 5 (DR5)/Fas-associated death domain (FADD)/caspase 8 pathway under ERS
Cytochrome P450-activated prodrugs
The University of Texas Health Science Center at Houston, Surgery Grand Rounds
