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Systemic Rejuvenation In landmark studies (Baar et al.), FOXO4-DRI administration in aged mice reversed signs of frailty, restored fur density, and improved renal function by clearing senescent cells from tissues

This method, based on a stapling strategy that employs formaldehyde to link amino acids, allows for the creation of multicyclic peptide topologies

Pain Physician 24 (6), 453463

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