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A preclinical study demonstrated that minocycline pretreatment significantly suppressed inflammatory microglial activation, alleviated pain, and restored locomotor function [155]

The main diagnostic guides i.e ., the DSM-5 edited by the American Psychological Association (APA) and the International Classification of Diseases 11 th Revision (ICD-11) published by the World Health Organization (WHO) are considering this problem

Muscle strength was objectively quantified using the hand grip strength test, whereas fatigue severity and its impact on daily life were subjectively assessed via the Patient-Reported Outcomes Measurement Information System Fatigue Computer-Adaptive Test [188, 189]

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