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In terms of ASCVD assessment, it is also important that clinicians are aware that patients with results just below these decision limits should also have concomitant assessment of other risk factors as that may increase their ASCVD risk further
Mechanistically, heme iron activates Toll-like receptor 4 (TLR4), driving nuclear factor B (NF-B) translocation and upregulating pro-inflammatory cytokines (TNF-, IL-6)
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