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Aiming to explore strategies to overcome these limitations, this review delves into nano-self-microemulsion delivery systems tailored for TGP, encompassing innovative techniques such as the synergistic integration of nobiletin and TGP, the employment of microemulsion formulations, and the elaboration of TGP liposomes, all aimed at enhancing the bioavailability of this promising natural compound

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Fetoni et al., 2015).The above studies have confirmed that curcumin has a significant dose-effect relationship, and there is an optimal concentration window--it can synergistically enhance the anticancer efficacy of cisplatin and minimize its toxic side effects