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A 2005 study demonstrated that both peptide and non-peptide GH secretagogues act through the GHS-R1a receptor but can also function as ghrelin receptor ligands with distinct binding properties, suggesting potential differences in downstream signaling despite shared receptor engagement
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Nature 471 (7337): 235-9, 2011
Aggregated S in turn reciprocally worsens mitochondrial stress and sirtuin loss, locking the system into a degenerative cycle that culminates in dopaminergic neuronal loss
