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Description
Vupanorsen (AKCEA-ANGPTL3-L Rx or IONIS-ANGPTL3-L Rx or ISIS 703802) is an N-acetylgalactosamine-conjugated antisense oligonucleotide targeting ANGPTL3

doi: 10.1097/GME.0000000000001043 188

Moreover, apart from Raynayds syndrome, on which data are somewhat limited, a study found that CRP is elevated in one quarter of scleroderma patients, especially early disease, and is correlated with disease activity and severity, and another study concluded that CRP can predict poor prognosis in individuals with systemic sclerosis [740,741]

C.SoejonoG.HarahapA
