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Experiments exposing rats to NO2, which mimics the inflammatory response in human COPD, revealed increased GPX3 mRNA expression and activity in bronchoalveolar lavage fluid (BALF) [121]

Bioactive phytochemicals of black cumin, comprising major and minor secondary metabolites, have been categorized into different chemical classes

Despite their clinical heterogeneity, these conditions share core pathological mechanisms including oxidative stress, chronic inflammation, hormonal imbalance, metabolic dysfunction, extracellular matrix remodeling, and dysregulated cell survival

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