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Description
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External validation of the Simplified Acute Physiology Score (SAPS) 3 in a cohort of 28,357 patients from 147 Italian intensive care units
Comprises three amino acids: Cysteine, Glutamic Acid, & Glycine
The ARE activation can initiate the transcription of downstream antioxidant protective genes and phase II detoxification enzyme genes, which translates into HO-1, superoxide dismutase (SOD), NQO1, catalase, glutathione peroxidase, glutamate-cysteine ligase, glutathione-S-transferase and epoxide hydrolase, etc
